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Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. As a polymerisation inhibitor, exploiting its antioxidant properties, hydroquinone prevents polymerization of acrylic acid, methyl methacrylate, cyanoacrylate, and other monomers that are susceptible to radical-initiated polymerization. It is understood that while the invention has been described in conjunction with the detailed description thereof, that the foregoing description is intended to illustrate and not limit the scope of the invention, which is defined by the scope of the appended claims. Inhalation Remove to fresh air. Thermodyn. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. Learn more about Institutional subscriptions, C. M. S. de Mendona, I. P. de Barros Lima, C. F. S. Arago, A. P. B. Gomes, J. Therm. Hydroquinone compositions are effective but have some undesirable side effects. Some documentation and label information may refer to the legacy brand. Conversion factors (at 25C and normal atmospheric pressure) 1 ppm = 4.5 mg/m 3 1 mg/m 3 = 0.222 ppm Table 1. HlRMo0WB:NnVCnE4(i0 (1* )@NzHR!>i;8XaXnsO0LNT0l$B%"NAb0I9V *6/-\vn0W"fKF:AAgl:psRZ?k`&eB IUQ0ET;W#vL=@XwRG{-LHlTz]^s%OB(GF 11'I Get medical attention. It is moderately soluble in water and highly soluble in alcohol. 0000000731 00000 n Then add it to the ingredients. How do I dissolve hydroquinone powder to make a 20% and 10% concentration? The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. If you have any specific questions, please include them in the comments section. 1 Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent. Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications The Boiling Point of hydroquinone is 287C Also, the Melting Point of hydroquinone is 172C. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Hydroquinone is combustible when preheated. 20grams ofhydroquinonein 20oz is liquid is 10%. 29(3): 283-330, 1999. Provided by the Springer Nature SharedIt content-sharing initiative, Over 10 million scientific documents at your fingertips, Not logged in stearic, palmitic, arachidic acids, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. Rev. Anal. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. Methylaminophenol, used in photography, is produced in this way:[8]. A method of stabilizing a hydroquinone composition, comprising hydroquinone and one or more protected retinoids, comprising: maintaining pH of the composition at about 5.5 to about 8.0. This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. . Unfortunately, retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) also have discoloration problems due to oxidation. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. We apologize! [Na+].OC[C@H](O)[C@H]1OC([O-])=C(OP([O-])([O-])=O)C1=O, N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1, C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21, CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C, disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate, [Na+]. It would be desirable to combine the pigmentation disorder treatment with this skin benefit ingredient in one composition. 38, 565571 (2006), K. Carlsson, B. Karlberg, Anal. 2017-02-16T10:10:56+01:00 How to dissolve Hydroquinone to make 4 oz. Forms of retinoids have been developed wherein the retinoid is protected by a protective system. Hydroquinone Safety Data Sheet according to Federal Register / Vol. Availability. 0000002585 00000 n Eng. At 40C, 4% hydroquinone compositions are more likely to excessively discolor and magnesium ascorbyl phosphate helps to stabilize the color, by preventing the brownish black discoloration and maintaining an amber color. J. Pharm. Conversion factors (at 25 oc and normal atmospheric pressure) 1 ppm = 4.5 mg!m 3 Hydroquinone is a white, odorless, crystalline solid with an extremely low vapor pressure. 0000005089 00000 n Adobe Acrobat 10.1.6 Paper Capture Plug-in COMMON BRAND NAME (S): Aclaro, Aclaro PD, Alera, Alphaquin HP, Alustra, Claripel, Complex B . HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. Editor's Rating: 330, 4851 (2012), A. Shalmashi, A. Eliassi, J. Chem. Diamines, useful in the rubber industry as antiozone agents, are similarly produced from aniline: Hydroquinone has a variety of uses principally associated with its action as a reducing agent that is soluble in water. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. 12.4. Part of Springer Nature. The solubility in water is 6.72g/L. Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. It has a white-solid appearance. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. Chim. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. Retinoid compositions, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin) are known to be effective in improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. [21] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Tests, which results are detailed in the following two tables, are performed at 5C and 40C for certain percentages of magnesium ascorbyl phosphate at specific pHs. While the hydroquinone is effective for the pigmentation disorder treatment, retinoid is used for its skin treatment benefits. Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . If you are already a ChemPoint customer then sign up for access to our online ordering website. ORIGINAL CODE: 0009013, Ref document number: fungichromin, Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. When the contents of the reservoir are forced into the reaction chamber, the catalases and peroxidases rapidly break down the hydrogen peroxide and catalyze the oxidation of the hydroquinones into p-quinones. endstream endobj 382 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /BCGJCE+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /XHeight 0 /FontFile2 389 0 R >> endobj 383 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 181 /Widths [ 250 0 0 0 0 0 0 278 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 333 333 0 570 0 0 0 722 667 722 722 667 611 778 778 389 500 778 667 944 722 778 611 778 722 556 667 722 722 1000 722 722 0 333 0 333 0 0 0 500 556 444 556 444 333 500 556 278 333 556 278 833 556 500 556 556 444 389 333 556 500 722 500 500 444 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 576 ] /Encoding /WinAnsiEncoding /BaseFont /BCGJCE+TimesNewRoman,Bold /FontDescriptor 382 0 R >> endobj 384 0 obj << /Type /FontDescriptor /Ascent 929 /CapHeight 0 /Descent -249 /Flags 32 /FontBBox [ -184 -249 1037 929 ] /FontName /BCGKAB+ImprintMT-Shadow /ItalicAngle 0 /StemV 0 /FontFile2 390 0 R >> endobj 385 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 122 /Widths [ 250 0 0 0 0 0 0 0 323 323 0 0 0 375 240 0 510 427 510 510 0 510 0 510 510 510 0 0 0 0 0 0 0 729 0 729 0 698 0 0 854 0 0 0 0 927 802 813 0 0 0 604 0 0 0 0 802 0 0 0 0 0 0 0 0 448 552 0 552 448 0 0 573 271 0 0 271 875 573 500 0 552 375 0 323 573 0 0 0 500 448 ] /Encoding /WinAnsiEncoding /BaseFont /BCGKAB+ImprintMT-Shadow /FontDescriptor 384 0 R >> endobj 386 0 obj << /N 3 /Alternate /DeviceRGB /Length 2575 /Filter /FlateDecode >> stream There are various other uses associated with its reducing power. Remove contact lenses, if present and easy to do. 0000053439 00000 n By clicking Accept, you consent to the use of cookies. Your document download will begin shortly. You can expect to hear back from a ChemPoint product specialist within 1 business hour. Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Sodium metabisulfite has the added advantage that it does not discolor by oxidation. F. Whler (1844) "Untersuchungen ber das Chinon" (Investigations of quinone). Thank you for your inquiry and interest in ChemPoint. The color stability of the hydroquinone composition is promoted by one or more antioxidants in the hydroquinone phase, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate. We have discovered that a hydroquinone composition (with about 1 to about 12% hydroquinone, preferably with about 2% to about 10%, more preferably with about 2% to about 8%, more preferably with about 2% to about 4%, most preferably with about 3% to about 4% hydroquinone) with preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, can include cationic salts of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate as an antioxidant and the color destabilization problems are appreciably less as compared to hydroquinone compositions without such a cationic salt of acidic ascorbyl esters in the neutral pH range: preferably a pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5. [34], It is also one of the chemical compounds found in castoreum. Hydroquinone is combustible when preheated. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. LSPS, Laboratoire de Spectrochimie Et Pharmacologie Structurale, University of Tlemcen, BP 119, 13000, Tlemcen, Algeria, Department of Biology, University of Ghardaia, BP 455, 47000, Ghardaia, Algeria, You can also search for this author in Hydroquinone is combustible when preheated. Hi, let us know if you have any questions as you visit our website. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. Calorim. 0.6. glycerin, 2.5. All information collection is solely used to support ChemPoint customers service communications. For use herein, the encapsulation forms a protective system to prohibit or inhibit the oxidation of the retinoid. Some documentation and label information may refer to the legacy brand. 88, 161164 (2010), J. Delgado, Int. endstream endobj 1 0 obj <> endobj 2 0 obj <> endobj 12 0 obj <>stream 0000002221 00000 n Hydroquinone can be made through several routes. Calorim. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. NR 1L~tyj|ZZ3]jFlszH#bd]="nVj =rBF-=Y?Pe 3(\[3;wR-+7Fn ~pSQ(Rpiw^zYr''t@\vobE]u'C}io0q;^k5C@|zZNNA>,XOrztV;qO*w:MC$OI\_$Io 'v [ A2, Designated state(s): I'm using it for spot treatment of some hyper pigmentation (less than 1% of my body). EP, Kind code of ref document: These can be burning, redness, sensitization and irritation in some patients. Eng. ;O,1Y+%8#oKT^VWtew4>@V.SR :hmBZ>#ey!UC5! / /n This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Color stability improvement is evident at all levels. 20, 14331442 (1986), G. Wienke, J. Gmehling, Toxicol. Hydroquinone occurs as fine, white needles. [33], Hydroquinone has been shown to be one of the chemical constituents of the natural product propolis. This website uses cookies. Free format text: The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25K to 334.45K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. Thermodyn. 322, 4855 (2012), K. Tamura, T. Kasuga, T. Nakagawa, Fluid Phase Equilib. Hydroquinone is an aromatic organic compound which is currently used in two main sectors: . 109. J. and our A further embodiment of the invention includes a method for stabilizing a hydroquinone composition (with about 1% to about 12% hydroquinone, preferably about 2% to about 10%, more preferably about 2% to about 8%, and most preferably about 3% to about 4%) with a neutral pH of from about 5.5 to about 8.0, more preferably a pH of from about 5.5 to about 7.5, and most preferably at a pH of from about 6.0 to about 7.5, by adding a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, preferably sodium ascorbyl phosphate, more preferably aminopropyl ascorbyl phosphate, most preferably magnesium ascorbyl phosphate. 2 Liquid phase only; silicon dioxide remains as a residue in these solvents. On this Wikipedia the language links are at the top of the page across from the article title. Environ. Preferably, the protected retinoid, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), is in the form of small beads or spheres suitable for incorporation into a topical composition. Chem. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. Hope it helps 6 yrs later. 0000008435 00000 n Correspondence to uuid:3780f5dc-b322-4e29-9b1d-4c4d10b1e282 wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 0 7 r @ &. You can expect to hear from a technical specialist within 1 business hour. Treatment with hydroquinone interferes with the action of tyrosinase, which is an enzyme used in the synthesis of melanin, and compositions are sold across the counter at about 2% hydroquinone and by prescription at higher concentrations. This is a prescription-only ingredient in some countries, including the member states of the European Union under Directives 76/768/EEC:1976. P, Kind code of ref document: Protected retinoid may be added to these compositions for additional skin benefit effects. Since hydroquinone has a tendency to discolor through oxidation, these antioxidants are used because they have greater tendencies to oxidize than hydroquinone. It is a reducing agent that is reversibly oxidized to semiquinone and quinone. For a shipping quote, check the box and the bottom and provide us your shipping information. The solubility was increased by addition of ethanol, reached a maximum . Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. trailer << /Size 393 /Info 347 0 R /Root 375 0 R /Prev 573815 /ID[<6893db2526a970a0c364cca2e99ca522>] >> startxref 0 %%EOF 375 0 obj << /Type /Catalog /Pages 346 0 R /Metadata 348 0 R >> endobj 391 0 obj << /S 2217 /Filter /FlateDecode /Length 392 0 R >> stream INCI HydroquinoneEastman Hydroquinone, USP is a skin care ingredient used to produce effective skin- lightening applications for depigmentation. However, hydroquinone discolors at the pH range of 7.0 to 8.5.